BioVin® French Red Grapes Extract

BioVin^® is made from the juice, seeds, and skins of French red grapes. It provides a full spectrum of grape’s health-promoting compounds (grapes contain thousands of compounds). Grape skins and seeds contain small amounts of trans-resveratrol. This compound has been the subject of hundreds of pre-clinical and clinical research studies. While trans-resveratrol has received a great deal of research attention, grapes are more than one compound: They contain resveratrol derivatives (e.g., viniferins, polydatin) and polyphenol compounds (e.g., oligomeric proanthocyanidins, quercetin, gallic acids, catechins). These compounds have complementarity with trans-resveratrol. We think it makes sense to use a full spectrum extract to capture these complementary activities.*

Top Benefits of BioVin^®

Supports healthy aging *

Supports mitochondrial health *

Supports cellular responses and antioxidant defenses *

Supports maintenance of healthy brain function *

Supports healthy gut microbiota *

Qualia’s BioVin^® Sourcing

BioVin^® is a full spectrum French red grape extract. Made from grape juice, seeds, and skins of Vitis vinifera, whole red grapes.

Standardized to contain 5% trans-resveratrol and not less than 40% grape oligomeric proanthocyanidins.

BioVin^® is from grapes responsibly grown and harvested in the Rhone Valley region of France.

BioVin^® is non-GMO and vegan.

BioVin^® Advanced is a registered trademark of Cyvex Nutrition, Inc dba Bioriginal.

BioVin^® Formulating Principles and Rationale

When thinking about the serving of BioVin® there’s a few things to keep in mind. This grape extract has been standardized to contain 5% trans-resveratrol and not less than 40% oligomeric proanthocyanidins. The extract also has other compounds that naturally occur in grape juice, seeds, and skin. While trans-resveratrol may be part of the reason we use this extract, it’s the complementarity of all of grape’s phytonutrients that is the story. Focusing only on resveratrol misses the big picture. That said, we don’t view resveratrol as a more is better compound—some studies have used resveratrol alone in amounts as low as 10 mg [1–4]. So, resveratrol might be better thought of as a hormetic substance; something that in low to moderate amounts supports an adaptive response to stress (see Qualia Dosing Principles).* Our goal with BioVin®, as with all ingredient choices, is to select an appropriate serving in the context of other ingredient complementarities. Depending on the product, the amount of Biovin® included will supply 2.5-10 mg of resveratrol and 20-80 mg of grape oligomeric proanthocyanidins. To get this amount of resveratrol would require drinking somewhere between 1-30 liters of red wine (red wine can vary quite a bit in resveratrol content).

BioVin^® Key Mechanisms 

Grape extract and proanthocyanidins

Supports mitochondrial structure and function*

Supports transcription factors associated with mitochondrial biogenesis (PGC-1α, NRF1, NRF2, TFAM)* [5–12]

Supports mitochondrial structure* [8]

Supports mitochondrial electron transport chain function* [13–18]

Supports the activities of TCA cycle enzymes* [17]

Supports β-oxidation* [15]

Supports the NAD+ pool* [19]

Supports brain function and cognition*

Supports cognitive function* [20–28]

Supports healthy sleep* [29]

Supports brain metabolism* [29]

Supports BDNF levels* [22,23,26,30–32]

Supports synaptic plasticity and long-term potentiation* [21,24,26,33] 

Supports neuroprotective functions* [24,27,28,34]

Supports neuronal mitochondrial function* [6,25]

Counters brain oxidative stress* [21,23,25,27,35] 

Supports a healthy mood and stress response*

Supports positive affect* [20,22,29,32]

Supports a calm mood* [20–23,25,29,35,36]

Influences stress hormone levels* [22,25,35]

Supports skin health* 

Influences melanin production* [37–39]

Supports healthy dermal ECM structure* [40,41] 

Supports skin Nrf2 signaling and phase II detox enzymes* [40]  

Supports healthy immune/cytokine signaling* [42] 

Supports skin in adapting to environmental stress* [40,42]

Supports a healthy gut microbiota*

Supports healthy gut microbiota* [43–48]

Supports gut barrier function* [47,49,50]

Counters gut oxidative stress* [50,51]

Promotes general health, healthy aging, and longevity* 

Supports maintenance of healthy vascular function and blood pressure* [29,52,52,53] Supports maintenance of muscle mass* [29]

Supports the insulin signaling pathway* [54]

Supports maintenance of healthy lipid metabolism* [13–15,54] 

Supports antioxidant defenses* [6–9,11,13,54]

Counters reactive oxygen species (ROS) levels and oxidative stress* [8,13,14,16,18,54]

Supports UCP1 and brown adipose tissue levels* [5]

Supports AMPK signaling* [7–9,11,15,54–56]

Supports SIRT1 levels* [6–9,19]

Counters mTOR signaling* [55]

Supports healthy circadian rhythms* [57,58]

Complementary ingredients*

Pomegranate fruit extract in supporting skin health* [59]

Resveratrol

Supports mitochondrial structure and function*

Supports healthy mitochondrial structure* [60–62]

Supports healthy mitochondrial function* [61,63,64]

Supports transcription factors associated with mitochondrial biogenesis (PGC-1α, NRF1, NRF2, TFAM)* [61–68]

Supports mitochondrial metabolic pathways of cell energy production* [61,63,65,67–69]

Supports NAD+ pool* [63,64,69]

Supports brain function*

Supports cognitive function in older adults* [70–78] 

Supports healthy cerebrovascular function* [70,77,79,80]

Supports neuroplasticity mechanisms* [81–83]

Supports brain-derived neurotrophic factor (BDNF) levels* [73–75,83–91]

Supports neuroendocrine signaling* [89,91]

Supports neuroprotective functions* [86,91–94]

Supports healthy neuroimmune and microglial function* [95–103]

Supports healthy immune function*

Supports innate immunity* [104–117]

Supports adaptive immunity* [117–123]

Supports immune signaling* [118,124–131]

Supports immune tolerance* [117–122,132–138]

Supports a healthy gut microbiota*

Supports healthy gut microbiota* [139–159]

Supports gut barrier function* [142]

Supports mucosal immunity* [160–162]

Supports healthy gut immune signaling* [145]

Supports skin health*

Supports healthy dermal ECM structure (collagen, elastin)* [40,163,164]  

Influences melanin production* [165–167]

Supports skin antioxidant defenses* [163,164,168,169] 

Supports skin Nrf2 signaling and phase II defenses* [40,168,170]  

Supports healthy skin immune signaling* [163,164,171]

Supports skin in adapting to environmental stress* [172–179]

Influences skin autophagy* [180]

Promotes healthy aging and longevity*

Supports Nrf2 signaling and antioxidant defenses* [94,181–192]

Supports stem cell function* [193–205]

Supports telomerase activity* [193–195,206,207]

Supports anti-senescence functions* [194,195,200,207]

Supports AMPK signaling* [2,62–65,67–69,208]

Supports SIRT1* [2,63,65,66,68,209–211]

Supports mitochondrial uncoupling and thermogenesis* [61,64]

Supports clock gene expression and circadian rhythms* [212–215]

Complementary ingredients*

Apigenin - resveratrol is an apigenin bioenhancer* [216]

Piperine as a bioenhancer [133,217–220] and for cognitive function* [221]

Hawthorn for heart function support* [222]

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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