Sensoril® Ashwagandha Withania somnifera Root and Leaf Extract

Ashwagandha is an Ayurvedic herb with adaptogenic properties—it’s often referred to as “Indian ginseng.” Ashwagandha has a long history of use and has been reported to have several health-promoting effects, supporting healthy energy, metabolism, stress response, physical performance, sleep, joint health, and cognitive performance. The novel active constituents are a group of plant compounds called withanolide glycosides. Sensoril® root and leaf extract is standardized for withanolide glycoside content.*

Top Benefits of Sensoril® Ashwagandha

Supports mitochondrial function* 

Supports exercise performance*

Supports healthy stress resistance*

Supports cognitive performance*

Supports sleep*

Qualia’s Sensoril^® Ashwagandha Sourcing

Sensoril^® has been clinically tested in 10 randomized, double-blind, placebo-controlled human trials.

Created by Natreon Inc., a leader in scientifically studied and tested Ayurvedic ingredients.

Leaf and root extract triple standardized to contain a minimum of 10% withanolide glycosides, the main bioactive; a minimum of 32% oligosaccharides, which increase the bioavailability of the withanolide glycosides; and a maximum of 0.5% free withanolides (as Withaferin A).

Protected by multiple U.S. patents with self-affirmed generally recognized as safe (GRAS) status). 

Sensoril^® is vegan, non-GMO, gluten-free, Kosher and Halal certified.

Sensoril^® Ashwagandha Formulating Principles and Rationale

We consider Ashwagandha to be an herbal adaptogen, so expect it to follow hormetic dosing principles (see Qualia Dosing Principles). Herbal adaptogens tend to have a hormetic zone (or range) where there’s a favorable biological response. It’s important to be in this zone; it’s just as important not to be above it. So, it’s important to identify the lowest amount that can produce the desired response. Sensoril®—the standardized extract we use—produced a threshold response in a study that gave different daily dosages—125 mg, 250 mg, 500 mg. Effect size was slightly greater for the higher doses, but most of the change was evident with the lowest dose [1]. We opted for this lower serving to be consistent with a core hormetic principle—only do or use as much as something as would be needed to stimulate the desired response.*

Withania somnifera Key Mechanisms 

Supports mitochondrial structure and function*

Supports mitochondrial function and structure* [2,3]

Supports electron transport chain activity* [2,4–6]

Supports citric acid cycle enzymes* [6]

Promotes exercise performance*

Supports endurance performance* [7,8]

Supports muscle strength* [9,10]

Supports post-exercise recovery* [10]

Supports healthy metabolism*

Supports healthy blood glucose levels* [11–17]

Supports healthy leptin signaling* [16,18]

Supports healthy feeding behaviors* [18,19]

Supports lean mass* [10]

Enhances antioxidant defenses*

Supports antioxidant defenses* [2,4,5,17,20]

Replenishes glutathione (GSH) levels* [2,4,17]

Counters ROS levels and oxidative stress* [2–4,21]

Supports brain function*

Supports cognitive performance* [22–24]

Supports GABA signaling* [25–29]

Supports dopamine signaling* [4]

Influences acetylcholinesterase activity* [4]

Supports neuroprotective functions* [2,4,5,21]

Influences neural immune signaling* [18,21]

Promotes healthy sleep*

Supports sleep onset and total sleep time* [28,30]

Supports sleep efficiency* [30]

Supports quality of sleep* [9,30]

Supports slow wave sleep* [28]

Supports healthy mood and stress response*

Supports a calm mood* [18,30,31]

Supports healthy stress responses* [1,19,32]

Supports healthy stress hormone levels* [1,19,31,32]

Supports healthy immune system function*

Supports innate immunity* [33–37]

Supports adaptive immunity* [33,34,37–46]

Supports immune system communication* [37,47–49]

Supports healthy immune signaling* [13,14,18]

Supports healthy thyroid function*

Supports thyroid function [50–52]

*These statements have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, cure, or prevent any disease.

REFERENCES

[1]B. Auddy, J. Hazra, A. Mitra, B. Abedon, S. Ghosal, Journal of American Nutraceutical Association 11 (2008) 50–56.

[2]A. Sood, A. Mehrotra, D.K. Dhawan, R. Sandhir, Metab. Brain Dis. 33 (2018) 1261–1274.

[3]P. Parihar, R. Shetty, P. Ghafourifar, M.S. Parihar, Cell. Mol. Biol. 62 (2016) 73–83.

[4]M.J. Manjunath, Muralidhara, J. Food Sci. Technol. 52 (2015) 1971–1981.

[5]P. Kumar, A. Kumar, J. Med. Food 12 (2009) 591–600.

[6]P. Senthilnathan, R. Padmavathi, V. Magesh, D. Sakthisekaran, Life Sci. 78 (2006) 1010–1014.

[7]J.S. Sandhu, B. Shah, S. Shenoy, S. Chauhan, G.S. Lavekar, M.M. Padhi, Int. J. Ayurveda Res. 1 (2010) 144–149.

[8]B. Choudhary, A. Shetty, D.G. Langade, Ayu 36 (2015) 63–68.

[9]A.A. Raut, N.N. Rege, F.M. Tadvi, P.V. Solanki, K.R. Kene, S.G. Shirolkar, S.N. Pandey, R.A. Vaidya, A.B. Vaidya, J. Ayurveda Integr. Med. 3 (2012) 111–114.

[10]S. Wankhede, D. Langade, K. Joshi, S.R. Sinha, S. Bhattacharyya, J. Int. Soc. Sports Nutr. 12 (2015) 43.

[11]S. Durg, S. Bavage, S.B. Shivaram, Phytother. Res. 34 (2020) 1041–1059.

[12]B. Andallu, B. Radhika, Indian J. Exp. Biol. 38 (2000) 607–609.

[13]M.R. Shahraki, Z. Samadi Noshahr, H. Ahmadvand, A. Nakhaie, J. Basic Clin. Physiol. Pharmacol. 27 (2016) 387–391.

[14]Z. Samadi Noshahr, M.R. Shahraki, H. Ahmadvand, D. Nourabadi, A. Nakhaei, Rep Biochem Mol Biol 3 (2015) 62–67.

[15]T. Anwer, M. Sharma, K.K. Pillai, M. Iqbal, Basic Clin. Pharmacol. Toxicol. 102 (2008) 498–503.

[16]J. Lee, J. Liu, X. Feng, M.A. Salazar Hernández, P. Mucka, D. Ibi, J.W. Choi, U. Ozcan, Nat. Med. 22 (2016) 1023–1032.

[17]T. Anwer, M. Sharma, K.K. Pillai, G. Khan, Acta Pol. Pharm. 69 (2012) 1095–1101.

[18]T. Kaur, G. Kaur, J. Neuroinflammation 14 (2017) 201.

[19]D. Choudhary, S. Bhattacharyya, K. Joshi, J. Evid. Based Complementary Altern. Med. 22 (2017) 96–106.

[20]S.K. Gupta, A. Dua, B.P.S. Vohra, Drug Metabol. Drug Interact. 19 (2003) 211–222.

[21]B.A. Akhoon, S. Pandey, S. Tiwari, R. Pandey, Exp. Gerontol. 78 (2016) 47–56.

[22]U. Pingali, R. Pilli, N. Fatima, Pharmacognosy Res. 6 (2014) 12–18.

[23]K.N.R. Chengappa, C.R. Bowie, P.J. Schlicht, D. Fleet, J.S. Brar, R. Jindal, J. Clin. Psychiatry 74 (2013) 1076–1083.

[24]D. Choudhary, S. Bhattacharyya, S. Bose, J. Diet. Suppl. 14 (2017) 599–612.

[25]A.K. Mehta, P. Binkley, S.S. Gandhi, M.K. Ticku, Indian J. Med. Res. 94 (1991) 312–315.

[26]J.P. Bhattarai, S.A. Park, S.K. Han, Phytotherapy Research (2009).

[27]H. Yin, D.H. Cho, S.J. Park, S.K. Han, The American Journal of Chinese Medicine 41 (2013) 1043–1051.

[28]A. Kumar, H. Kalonia, Indian J. Pharm. Sci. 70 (2008) 806–810.

[29]M. Candelario, E. Cuellar, J.M. Reyes-Ruiz, N. Darabedian, Z. Feimeng, R. Miledi, A. Russo-Neustadt, A. Limon, J. Ethnopharmacol. 171 (2015) 264–272.

[30]D. Langade, S. Kanchi, J. Salve, K. Debnath, D. Ambegaokar, Cureus 11 (2019) e5797.

[31]A. Remenapp, K. Coyle, T. Orange, T. Lynch, D. Hooper, S. Hooper, K. Conway, H.A. Hausenblas, J. Ayurveda Integr. Med. 13 (2021) 100510.

[32]K. Chandrasekhar, J. Kapoor, S. Anishetty, Indian J. Psychol. Med. 34 (2012) 255–262.

[33]L. Davis, G. Kuttan, J. Exp. Clin. Cancer Res. 21 (2002) 585–590.

[34]J. Mikolai, A. Erlandsen, A. Murison, K.A. Brown, W.L. Gregory, P. Raman-Caplan, H.L. Zwickey, J. Altern. Complement. Med. 15 (2009) 423–430.

[35]J. Bhat, A. Damle, P.P. Vaishnav, R. Albers, M. Joshi, G. Banerjee, Phytother. Res. 24 (2010) 129–135.

[36]A. Barua, M.J. Bradaric, P. Bitterman, J.S. Abramowicz, S. Sharma, S. Basu, H. Lopez, J.M. Bahr, Am. J. Reprod. Immunol. 70 (2013) 538–550.

[37]F. Malik, A. Kumar, S. Bhushan, D.M. Mondhe, H.C. Pal, R. Sharma, A. Khajuria, S. Singh, G. Singh, A.K. Saxena, K.A. Suri, G.N. Qazi, J. Singh, Eur. J. Cancer 45 (2009) 1494–1509.

[38]L. Davis, G. Kuttan, J. Ethnopharmacol. 71 (2000) 193–200.

[39]M. Gautam, S.S. Diwanay, S. Gairola, Y.S. Shinde, S.S. Jadhav, B.K. Patwardhan, Int. Immunopharmacol. 4 (2004) 841–849.

[40]S. Bani, M. Gautam, F.A. Sheikh, B. Khan, N.K. Satti, K.A. Suri, G.N. Qazi, B. Patwardhan, J. Ethnopharmacol. 107 (2006) 107–115.

[41]F. Malik, J. Singh, A. Khajuria, K.A. Suri, N.K. Satti, S. Singh, M.K. Kaul, A. Kumar, A. Bhatia, G.N. Qazi, Life Sci. 80 (2007) 1525–1538.

[42]G. Muralikrishnan, A.K. Dinda, F. Shakeel, Immunol. Invest. 39 (2010) 688–698.

[43]K. Yamada, P. Hung, T.K. Park, P.J. Park, B.O. Lim, J. Ethnopharmacol. 137 (2011) 231–235.

[44]S.K. Latheef, K. Dhama, H.A. Samad, M.Y. Wani, M.A. Kumar, M. Palanivelu, Y.S. Malik, S.D. Singh, R. Singh, Virusdisease 28 (2017) 115–120.

[45]S.P. Maurya, B.K. Das, R. Singh, S. Tyagi, Clin. Immunol. 203 (2019) 122–124.

[46]R. Kumar, J. Rai, N.C. Kajal, P. Devi, Indian J. Tuberc. 65 (2018) 246–251.

[47]B. Khan, S.F. Ahmad, S. Bani, A. Kaul, K.A. Suri, N.K. Satti, M. Athar, G.N. Qazi, Int. Immunopharmacol. 6 (2006) 1394–1403.

[48]C.D.P. Tripathi, P.K. Kushawaha, R.S. Sangwan, C. Mandal, S. Misra-Bhattacharya, A. Dube, Phytomedicine 24 (2017) 87–95.

[49]T. Kaur, H. Singh, R. Mishra, S. Manchanda, M. Gupta, V. Saini, A. Sharma, G. Kaur, Mol. Cell. Biochem. 427 (2017) 91–101.

[50]A.K. Sharma, I. Basu, S. Singh, J. Altern. Complement. Med. 24 (2018) 243–248.

[51]J.M. Gannon, P.E. Forrest, K.N. Roy Chengappa, J. Ayurveda Integr. Med. 5 (2014) 241–245.

[52]R. Jatwa, A. Kar, Phytother. Res. 23 (2009) 1140–1145.